Hormones and Psoriasis

The link between prominent hormones and chronic skin problems

Hormones and PsoriasisPsoriasis is an inflammatory disease, and hormones are notoriously taxing – combine the two and you could have an unhappy mixture of burning pain, itching, scaly, and downright frustrating symptoms. The relationship between psoriasis and hormonal fluctuations isn’t completely understood, but there’s strong evidence to suggest a link, and it’s important to learn how your skin can react to different phases in order to limit the damage and discomfort.

How Psoriasis Behaves in Times of Hormonal Fluctuation

Female hormones can have a big effect on how psoriasis manifests, so although just as many men suffer from psoriasis as women, they may not experience symptom variations in the same way. Researchers have found that psoriasis symptoms tend to spike more often during puberty, after pregnancy, and during menopause.

The results indicate that sex hormones are partly to blame for psoriasis flares, but it’s difficult to tell just how they interfere with the body’s inflammatory response. However, there are a few promising theories to explain the link:

  • Sex hormone levels alter immune response after the first period. When young women experience menarche (their first menstrual period), estrogen and other sex hormone levels increase, which may activate certain T-cells in the body. These T-cells trigger an immune response, which can manifest as psoriasis flare-ups during puberty.
  • More estrogen during pregnancy reduces inflammation. Experts believe that estrogen’s anti-inflammatory effect is responsible for the reduction of psoriasis symptoms during pregnancy. Over half of women with psoriasis notice improvement in their skin while they’re pregnant, and 65% see their condition worsen after they give birth – when estrogen levels fall again.
  • Less estrogen after menopause leads to exacerbations. As if the regular range of menopausal discomforts weren’t enough, women with psoriasis often see a marked increase in symptoms. Almost 50% of women find the intensity and coverage of their psoriasis plaques and scales get worse, and since estrogen therapy comes with some alarming risks, it’s not easy to counter this spike in skin symptoms.

There certainly seems to be a connection between estrogen and psoriasis flares, but the interactions of sex hormones aren’t always so straightforward. After all, more estrogen may mean less skin problems for the majority of women, but around one quarter of pregnant psoriasis sufferers find their skin actually gets worse during pregnancy, and 10% even notice improvement in the postpartum period. Since many sex hormones occur in different ratios and work in different ways, it’s nearly impossible to predict how their specific interactions will affect your autoimmune response.


Psoriasis and Leptin

Leptin is a naturally-occurring hormone in the body, responsible for regulating food intake and fat stores. High leptin levels are associated with weight gain and inflammation – two processes that often go hand in hand. In fact, psoriasis patients (who live with chronic inflammation) are more than twice as likely to be obese or suffer from high blood pressure, which also puts them at risk for other chronic diseases.

Recent research shows that people with psoriasis have elevated leptin levels, whether or not they are overweight. This excess of leptin in the blood may contribute to risk of heart disease, diabetes, and hypertension that comes with psoriasis. On the bright side, weight loss has been found to significantly decrease leptin levels, and reduce the risk of metabolic and cardiovascular diseases.

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